7528-15-6Relevant academic research and scientific papers
Unprecedented synthesis of alkynylphosphine-boranes through room-temperature oxidative alkynylation
Jouvin, Kevin,Veillard, Romain,Theunissen, Cedric,Alayrac, Carole,Gaumont, Annie-Claude,Evano, Gwilherm
, p. 4592 - 4595 (2013/09/24)
An original and user-friendly synthesis of alkynylphosphine-boranes, useful building blocks in organic synthesis, based on an oxidative P-alkynylation reaction with readily available copper acetylides is reported. The ability of a secondary phosphine protected with a borane to undergo oxidative coupling without oxidation of the P-moiety is demonstrated for the first time. The reaction, which proceeds at room temperature, is applicable to the preparation of enantioenriched and structurally complex alkynylphosphine-boranes.
