75288-20-9Relevant academic research and scientific papers
2,7-Diazabicyclo[2.2.1]heptanes: Novel asymmetric access and controlled bridge-opening
Peczkowski, Gary R.,Craven, Philip G. E.,Stead, Darren,Simpkins, Nigel S.
, p. 4214 - 4217 (2019)
Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2
INHIBITORS OF HIF PROLYL HYDROXYLASE
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Page/Page column 111-112, (2016/04/20)
The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
Rhodium-catalyzed coupling of α-lactams with indole derivatives
Box, Hannah K.,Upul Kumarasinghe,Nareddy, Radhika R.,Akurathi, Gopalakrishna,Chakraborty, Amarraj,Raji, Babatunde,Rowland, Gerald B.
, p. 9709 - 9717 (2015/02/02)
We report herein a method that allows for the formation of a C-N bond between the C-3 carbon of α-lactams and the nitrogen atom of indoles. A general procedure for the coupling of indoles and α-lactams in only 25 min with high yield is reported. The scope of the reaction was extended by the development of a method for the in situ generation of less stable phenyl-substituted α-lactams. The developed method provides an atom-economical method for the formation of substituted α-amino amides that are found in a variety of biologically-active compounds.
Copper(II)-catalyzed synthesis of pyrazinones from α-Azido-N- allylamides under an oxygen atmosphere
Zhang, Line,Lee, Jian-Yuan,Yamazaki, Naomi,Chiba, Shunsuke
, p. 2167 - 2170 (2011/10/18)
A copper(II)-catalyzed reaction of -azido-N-allylamide synthetic under an oxygen atmosphere resulted in the formation of 2-formyl pyrazinones. The present transformation was characterized by the following steps: 1) 1,3-dipolar cycloaddition of the azido part onto the intramolecular alkene to give bicyclic aziridine intermediates; 2) further copper(II)-catalyzed oxygenation-oxidation of the aziridines to give 2-formyl pyrazinones. Georg Thieme Verlag Stuttgart · New York.
1,3-Dipolar Character of Six-membered Aromatic Rings. Part 52. 2?+8? Cycloaddition Reactions of 1-Substituted 3-Oxidopyridinium Betaines
Katritzky, Alan R.,Cutler, Alan T.,Dennis, Nicolas,Sabongi, Gebran J.,Rahimi-Rastgoo, Soheila,et al.
, p. 1176 - 1184 (2007/10/02)
Dichloroketen and a series of aryl(bromo)ketens react with various 1-substituted 3-oxidopyridiniums to give novel bicyclic compounds by addition across the C(4)-O and the C(2)-O positions.Frontier-MO theory is used to rationalise the orientation of these cycloadditions.Acid-catalysed hydrolysis of the C(2)-O adducts (9) yielded 3-hydroxy-2-benzylpyridines.
