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14,15-Leukotriene C4 (14,15-LTC4) is a member of the leukotriene family, which are acute inflammatory mediators derived from arachidonic acid in leukocytes. It is synthesized through an alternate pathway involving the dual actions of 15and 12-lipoxygenases (LOs) on arachidonic acid, producing 15-HpETE and 14,15-LTA4 intermediates. Classified as an eoxin, 14,15-LTC4 is primarily formed by eosinophils but can also be synthesized by mast cells and nasal polyps. Although its physiological actions are not well understood, it exhibits weak contractile activity on guinea pig ileum and pulmonary parenchyma and can increase vascular permeability in human endothelial cell monolayers, contributing to plasma leakage and inflammation.

75290-60-7

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75290-60-7 Usage

Uses

Used in Pharmaceutical and Biomedical Research:
14,15-Leukotriene C4 is used as a research compound for studying its role in acute inflammation and immune responses. Understanding its mechanisms of action can help in the development of targeted therapies for various inflammatory conditions.
Used in Drug Development:
14,15-LTC4 is utilized as a lead compound in the development of new drugs aimed at modulating the inflammatory response. Its unique structure and activity make it a valuable starting point for designing novel anti-inflammatory agents.
Used in Diagnostics:
14,15-Leukotriene C4 can be used as a biomarker in the diagnosis of inflammatory diseases, as its presence may indicate an ongoing inflammatory process. Measuring levels of 14,15-LTC4 in biological samples can provide insights into the severity and progression of the disease.
Used in Toxicology and Environmental Studies:
14,15-LTC4 can be employed in toxicological and environmental research to evaluate the inflammatory effects of various substances, pollutants, or allergens. This can help in understanding the potential health risks associated with exposure to these agents and inform safety regulations.
Used in Cell Biology and Signal Transduction Research:
14,15-Leukotriene C4 is used as a tool in cell biology and signal transduction studies to investigate the cellular pathways and mechanisms involved in inflammation. This can contribute to a better understanding of the complex interactions between cells and their microenvironment during inflammatory processes.

Check Digit Verification of cas no

The CAS Registry Mumber 75290-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,9 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 75290-60:
(7*7)+(6*5)+(5*2)+(4*9)+(3*0)+(2*6)+(1*0)=137
137 % 10 = 7
So 75290-60-7 is a valid CAS Registry Number.

75290-60-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 14,15-Leukotriene C4

1.2 Other means of identification

Product number -
Other names EOXIN C4

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75290-60-7 SDS

75290-60-7Downstream Products

75290-60-7Relevant academic research and scientific papers

CHEMICAL CONVERSION OF ARACHIDONIC ACID TO SLOW REACTING SUBSTANCES

Corey, E. J.,Barton, Alan E.

, p. 2351 - 2354 (2007/10/02)

The synthesis of slow reacting substances, leukotrienes C, D, and E, can be accomplished conveniently by a stereoselective biomimetic route.Details are provided for the conversion of 5-HPETE methyl ester 4 to leukotriene methyl ester (2) and thence to leukotrienes C and D.

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