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14,15-Leukotriene D4 (14,15-LTD4) is a member of the leukotriene family, specifically an eoxin (EXD4), synthesized by a pathway involving the dual actions of 15and 12-lipoxygenases (15and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. It is primarily formed by eosinophils but can also be synthesized by mast cells and nasal polyps. 14,15-LTD4 has weak contractile activity on guinea pig ileum and pulmonary parenchyma, but it can increase vascular permeability in human endothelial cell monolayers, similar to the effects of 5-LO-derived leukotrienes, which is a characteristic of inflammation.

75290-64-1

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75290-64-1 Usage

Uses

Used in Pharmaceutical Industry:
14,15-LEUKOTRIENE D4 is used as a research compound for understanding its role in inflammation and potential therapeutic applications. Its ability to increase vascular permeability makes it a valuable tool for studying the underlying mechanisms of inflammatory processes and the development of targeted treatments for various inflammatory diseases.
Used in Research and Development:
14,15-LEUKOTRIENE D4 is used as a biochemical marker for investigating the involvement of eoxins in various physiological and pathological conditions. Its synthesis by eosinophils, mast cells, and nasal polyps makes it a relevant molecule for studying the interplay between these cell types and their contribution to inflammation and immune responses.
Used in Drug Discovery:
14,15-LEUKOTRIENE D4 is used as a target for the development of new drugs aimed at modulating its effects on vascular permeability and inflammation. Understanding the molecular interactions of 14,15-LTD4 with its receptors and downstream signaling pathways can lead to the design of novel therapeutic agents that can either enhance or inhibit its activity, depending on the desired therapeutic outcome.

Check Digit Verification of cas no

The CAS Registry Mumber 75290-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,9 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75290-64:
(7*7)+(6*5)+(5*2)+(4*9)+(3*0)+(2*6)+(1*4)=141
141 % 10 = 1
So 75290-64-1 is a valid CAS Registry Number.

75290-64-1Downstream Products

75290-64-1Relevant academic research and scientific papers

CHEMICAL CONVERSION OF ARACHIDONIC ACID TO SLOW REACTING SUBSTANCES

Corey, E. J.,Barton, Alan E.

, p. 2351 - 2354 (2007/10/02)

The synthesis of slow reacting substances, leukotrienes C, D, and E, can be accomplished conveniently by a stereoselective biomimetic route.Details are provided for the conversion of 5-HPETE methyl ester 4 to leukotriene methyl ester (2) and thence to leukotrienes C and D.

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