752969-87-2Relevant academic research and scientific papers
Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin
Tomishima, Masaki,Ohki, Hidenori,Yamada, Akira,Maki, Katsuyuki,Ikeda, Fumiaki
, p. 2886 - 2890 (2008/12/23)
Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 with an excellent, well-balanced profile. Potent compounds with reduced hemolytic potential were designed based upon a disruption of the linearity of the terphenyl lipophilic side chain. The optimized compound (8, FK463, micafungin) displayed the best balance and was selected as the clinical candidate.
