753007-86-2

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 753007-79-3 1-[2-acetyloxymethyl-3,5-bis-O-(t-butyldimethylsilyl)-2-deoxy-4-thio-β-D-arabinofuranosyl]thymine 
• 65-71-4 thymin 
• 209048-61-3 1,4-anhydro-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-4-thio-D-erythro-pent-1-enitol 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 649570-99-0 1,4-anhydro-1-chloro-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisioxane-1,3-diyl)-4-thio-D-erythro-pento-1-enitol 
• 753007-70-4 1,4-anhydro-1-chloro-2-deoxy-2-hydroxymethyl-3,5-O-(1,1,3,3-tetraisopropyldisioxane-1,3-diyl)-4-thio-D-erythro-pento-1-enitol 
• 753007-71-5 2-acetyloxymethyl-1,4-anhydro-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisioxane-1,3-diyl)-4-thio-D-erythro-pento-1-enitol 
• 753007-74-8 1-[2-acetyloxymethyl-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisioxane-1,3-diyl)-4-thio-β-D-arabinofuranosyl]thymine 
• 753007-72-6 1-[2-acetyloxymethyl-2-deoxy-2-phenylseleno-3,5-O-(1,1,3,3-tetraisopropyldisioxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]thymine 

Downstream Products

• 753007-87-3 N³-benzyloxymethyl-1-[3,5-bis-O-(t-butyldimethylsilyl)-2-deoxy-2-hydroxymethyl-4-thio-β-D-arabinofuranosyl]thymine 
• 753007-88-4 N³-benzyloxymethyl-1-[2-deoxy-3,5-bis-O-(t-butyldimethylsilyl)-2-fluoromethyl-4-thio-β-D-arabinofuranosyl]thymine 

Relevant academic research and scientific papers

Novel stereoselective entry to 2′-β-carbon-substituted 2′-deoxy-4′-thionucleosides from 4-thiofuranoid glycals

2β-β-Methyl- and 2′-β-hydroxymethyl-2′-deoxy- 4′-thionucleosides have been synthesized through PhSeCl-mediated electrophilic glycosidation using 4-thiofuranoid glycals having carbon substituents at the C2-position as a glycosyl donor. Preparation of these glycals were carried out by means of the C2 lithiation of 1-chloro-4- thiofuranoid glycal with LTMP followed by the Birch reduction of the chlorine atom.