753010-18-3

Basic information

• Product Name: tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-iodobutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate
• Synonyms: tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-iodobutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate
• CAS NO: 753010-18-3
• Molecular Weight: 551.421
• Mol File: 753010-18-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-iodobutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-iodobutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate(753010-18-3)
• EPA Substance Registry System: tert-butyl (3S,5S,6R)-3-[(3R)-3-hydroxy-4-iodobutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate(753010-18-3)

Safety Data

• Hazardous Substances Data: 753010-18-3(Hazardous Substances Data)

Upstream product

• 144542-72-3 (3S,5S,6R)-4-(tert-butyloxycarbonyl)-5,6-diphenyl-3-(3'-butenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 112741-49-8 tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate 
• 937183-38-5 tert-butyl (3S,5S,6R)-3-(2-((RS)oxiran-2-yl)ethyl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate 

Downstream Products

• 937183-43-2 C₇₅H₈₂N₄O₁₄ 
• 93923-90-1 (2S,5R)-5-hydroxylysine monohydrochloride 
• 753010-16-1 tert-butyl (3S,5S,6R)-3-[(3R)-4-azido-3-hydroxybutyl]-2-oxo-5,6-diphenyl-1,4-oxazine-4-carboxylate 

Relevant articles and documents

A practical and simple synthesis of (2S,5R)- and (2S,5S)-5-hydroxylysine and of a related α-amino acid required for the synthesis of the collagen cross-link pyridinoline

A four step synthesis of (2S,5R)- and (2S,5S)-5-hydroxylysine using Williams' glycine template methodology for controlling the stereogenicity at the α-position is reported. This route offers the possibility for the synthesis of all possible isomers of 5-hydroxylysine and of an important α-amino acidic iodohydrin required for the construction of the hydroxylated side chain of the collagen cross-link pyridinoline.