753012-80-5Relevant academic research and scientific papers
Synthesis and structural characteristics of geminally disubstituted β-amino acids
Fuller, Amelia A.,Chen, Bin,Minter, Aaron R.,Mapp, Anna K.
, p. 1409 - 1413 (2004)
The syntheses of seven new β-amino acids containing aryl, alkyl, and heteroaryl substituents are outlined. The synthetic strategy employs densely functionalized chiral isoxazolines as key intermediates, enabling the preparation of single stereoisomers of these challenging targets. Solid-state characterization of two of the sterically encumbered targets is also reported.
