753026-70-9Relevant academic research and scientific papers
Glucosylceramide synthase inhibitors
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Page/Page column 97, (2015/09/28)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
Gündisch, Daniela,Andr?, Matthias,Munoz, Lenka,Cristina Tilotta, Maria
, p. 4953 - 4962 (2007/10/03)
Phenylcarbamate derivatives were synthesized and evaluated in radioligand binding assays for different nicotinic acetylcholine receptor (nAChR) subtypes. Carbamate derivatives bearing a pyrrolidine or piperidine moiety 8-20 exhibited much lower affinity f
AZABICYCLIC ESTERS OF CARBAMIC ACIDS USEFUL IN THERAPY
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, (2008/06/13)
A compound of formula X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C-R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5, --CN, --CONH 2, --CO 2 R 5, --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2, --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5, --CN, --CONH 2, --CO 2 R 5, --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2, --CN, or --OCH 3 ; or R 2 and R 3 or R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2, --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis
