75304-24-4Relevant academic research and scientific papers
Synthesis and QSAR modeling 1-[3-methyl-2-(aryldiazenyl)-2H-aziren-2-yl] ethanones as potential antibacterial agents
Sahu, Vinita,Sharma, Pratibha,Kumar, Ashok
, p. 2476 - 2485 (2013/07/26)
The present communication deals with the synthesis of a series of 1-[3-methyl-2-(aryldiazenyl)-2H-aziren-2-yl]ethanones. The compounds were synthesized in excellent yields (70-80 %), and the structures were established on the basis of consistent IR, 1H NMR, and elemental analysis data. The purity has been ascertained by chromatographic resolution using hexane-ethyl acetate (6:4 v/v) as binary eluent. All the compounds have been tested for their antimicrobial activity against a representative panel of bacteria i.e., Bacillus subtilis, Escherichia coli, Pseudomonas diminuta, and Staphylococcus aureus using Chloramphenicol as reference drug. All the synthesized compounds were found to exhibit profound antimicrobial activity.
Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety
Amir, Mohd.,Javed, Sadique A.,Hassan, Mohd. Zaheen
experimental part, p. 1261 - 1270 (2012/07/31)
A new class of 4-arylhydrazono-1-benzothiazolyl-3-methylpyrazolin-5-ones (3a-j) and 4-arylazo-1-benzothiazolyl-3,5-dimethylpyrazoles (4a-j) were designed as pharmacophore hybrids between pyrazolinone/pyrazole and benzothiazole moiety. The target molecules were efficiently synthesized by the cyclization of various oxobutyrates/pentane-2,4-dione derivatives with 6-chloro-2- hydrazinobenzothiazole in the presence of glacial acetic acid. The compounds were evaluated for their in vitro antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electron-withdrawing groups in phenyl ring had a promising effect on the antimicrobial activity. Also, correlation study has been used to establish the relationships between the antibacterial activity and physicochemical parameter clogP. Springer Science+Business Media, LLC 2011.
Pyridazine derivatives and related compounds. 23*. synthesis of 3-substituted pyrazolo[3,4-c] pyridazines and their application as disperse dyes
Deeb,Yassin,Ouf,Shehta
experimental part, p. 212 - 222 (2011/08/21)
Acetylacetone and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones and arylazomalononitriles. When refluxed with 3-hydrazino-4,5-diphenyl-1H-pyrazolo-[3,4-c]pyridazine in the presence of ethanol/HCl, they yielded the corresponding 3-[4-(arylazo)-3,5-dimethylpyrazol- 1-yl]- and 3-[3,5-diamino-4-(arylazo)pyrazol-1-yl]-4,5-diphenyl-1H-pyrazolo[3,4- c]pyridazine dyes. The dyes were applied to polyester and polyamide fabrics, and their spectral and fastness properties were measured.
Antibacterial and antifungal studies on some new acetylcinnolines and cinnolinyl thiazole derivatives
Narayana,Raj, K. K. Vijaya,Ashalatha,Kumari, N. Suchetha
, p. 1704 - 1709 (2007/10/03)
Synthesis of some new 3-acetylcinnolines 2a-d has been carried out by the intramolecular cyclisation of phenylhydrazonoacetylacetone 1a-d. 3-Acetyl-4,8-dimethylcinnoline 2b has been converted to 3-(bromoacetyl)-4,8- dimethylcinnoline 3b. The 3-(bromoacetyl)-4,8-dimethylcinnoline 3b has then been treated with thioacetamide 4a, thiourea 4b and substituted thioureas 4c-f in ethanol to get 4-(4,8-dimethylcinnolin-3-yl)-2-methyl-1,3-thiazole 5a, 4-(4,8-dimethylcinnolin-3-yl)-2-amino-1,3-thiazole 5b and N- (aryl)-4-(4,8-dimethylcinnolin-3-yl)-1,3-thiazol-2-amines 5c-f. The newly synthesized compounds have been characterized by elemental analysis, IR, 1HNMR and mass spectral studies. Compounds have been screened for their antifungal and antibacterial activity. 4,7-dimethyl-3-acetylcinnoline 2c has emerged as a promising antibacterial agent and N-(3-chlorophenyl)-4-(4,8- dimethylcinnolin-3-yl)-1,3-thiazol-2-amine 5d has emerged as a promising antifungal agent.
