75318-43-3

Basic information

• Product Name: 4,5-DICHLORO-1,2,3-DITHIAZOLIUM CHLORIDE
• Synonyms: 4,5-Dichloro-1,2,3-dithiazol-1-ium chloride;Appel salt;4,5-Dichloro-1,2,3-dithiazolium chloride;D14145;4,5-DICHLORO-1,2,3-DITHIAZOLIUM;4,5-Dichloro-1,2,3-dithiazol-2-ylium chloride;4,5-Dichlorodithiazol-2-ium chloride;Appel's Salt
• CAS NO: 75318-43-3
• Molecular Formula: C₂Cl₂NS₂*Cl
• Molecular Weight: 208.52
• Mol File: 75318-43-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 172° (dec)
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4,5-DICHLORO-1,2,3-DITHIAZOLIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-1,2,3-DITHIAZOLIUM CHLORIDE(75318-43-3)
• EPA Substance Registry System: 4,5-DICHLORO-1,2,3-DITHIAZOLIUM CHLORIDE(75318-43-3)

Safety Data

• Hazardous Substances Data: 75318-43-3(Hazardous Substances Data)

Usage

Uses

Synthon in heterocyclic chemistry; in conversion of alcohols and carboxylic acids to esters.

Upstream product

• 107-14-2 chloroacetonitrile 
• 75-09-2 dichloromethane 
• 590-17-0 cyanomethyl bromide 
• 557-66-4 ethanamine hydrochloride 

Downstream Products

• 97272-66-7 4-Chlor-5-(2-hydroxy-5-methyl-phenyl)-1,2,3-dithiazolium-chlorid 
• 75318-49-9 N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline 
• 75318-48-8 N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-nitrobenzenamine 
• 97272-87-2 4-Chlor-5-(4-sulfamoylphenylimino)-5H-1,2,3-dithiazol 
• 75318-45-5 4-Chlor-5-(phenylimino)-5H-1,2,3-dithiazol-hydrochlorid 
• 853995-67-2 methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4,5-dimethoxyanthranilate 
• 169778-78-3 methyl N-(cyanothioformyl)anthranilate 
• 853995-64-9 methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-anthranilate 
• 180723-56-2 5-Cyano-3-phenyl-1,2,4-thidiazole-4-oxide 
• 100-47-0 benzonitrile 
• 65342-88-3 N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)benzenamine 
• 65343-08-0 4-chloro-5-(2-cyanophenylimino)-5H-1,2,3-dithiazole 

Relevant articles and documents

Solid-phase synthesis of 2-cyanoquinazolin-4(3H)-one and 2,3-dihydrooxazolo[2,3-b]quinazolin-5-one derivatives utilizing resin-bound anthranilic acid derivatives

We were able to obtain 2-cyanoquinazolin-4(3H)-ones 11 in 35-60% four-step overall isolated yields and 2,3-dihydrooxazolo[2,3-b]quinazolin-5-ones 12 in 20-71% four-step overall isolated yields utilizing polymer-bound anthranilic acid derivatives 1, and 6-amino-2-cyanoquinazolin-4(3H)-ones 19 in 30-44% six-step overall isolated yields making use of anthranilic acid derivative resin 2 via dithiazole resins 10 and 17. The reactions on solid phase were monitored by single bead ATR-FTIR spectroscopic method.

DERIVATIVES OF LUCIFERIN AND METHODS FOR THEIR SYNTHESIS

6-Thio derivatives of D-luciferin, also referred to as D-thioluciferins, having the general structure of Formula (I) are provided. Methods for synthesising D-luciferin, its derivatives, and their related 2-cyanobenzothiazole precursors are also provided. These compounds are commercially valuable due to their application in optical imaging, particularly in bioluminescence imaging.

Rapid and scalable assembly of firefly luciferase substrates

Bioluminescence imaging with luciferase-luciferin pairs is a popular method for visualizing biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain prohibitively expensive for some imaging applications. Here we report cost-effective and efficient syntheses of d-luciferin and 6′-aminoluciferin, two widely used bioluminescent substrates. Our approach employs inexpensive anilines and Appel's salt to generate the luciferin cores in a single pot. Additionally, the syntheses are scalable and can provide multi-gram quantities of both substrates. The streamlined production and improved accessibility of luciferin reagents will bolster in vivo imaging efforts. This journal is