7533-39-3Relevant academic research and scientific papers
IMIDAZOPYRIDINE COMPOUNDS
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Paragraph 0265; 0374, (2015/11/11)
[Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having
Enantioselective rhodium-catalyzed arylation of cyclic N -sulfamidate alkylketimines: A new access to chiral β-alkyl-β-aryl amino alcohols
Chen, Ya-Jing,Chen, Ya-Heng,Feng, Chen-Guo,Lin, Guo-Qiang
supporting information, p. 3400 - 3403 (2014/07/08)
The enantioselective rhodium-catalyzed 1,2-addition of arylboronates to cyclic N-sulfamidate alkylketimines was developed. With a rhodium/diene complex as catalyst, high enantioselectivity and broad functional group tolerance were observed. The resulting sulfamidates can easily be converted into chiral β-alkyl-β-aryl amino alcohols.
Direct catalytic asymmetric alkynylation of ketoimines
Yin, Liang,Otsuka, Yasunari,Takada, Hisashi,Mouri, Shinsuke,Yazaki, Ryo,Kumagai, Naoya,Shibasaki, Masakatsu
supporting information, p. 698 - 701 (2013/04/11)
An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.
