753392-43-7

Upstream product

• 56327-10-7 Acetic acid 1-(4-chloro-phenyl)-4-hydroxy-cyclohexylmethyl ester 
• 56327-06-1 Acetic acid 1-(4-chloro-phenyl)-4-oxo-cyclohexylmethyl ester 
• 56327-02-7 8-(4-chloro-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid 
• 56327-15-2 Acetic acid 1-(4-chloro-phenyl)-4-methanesulfonyloxy-cyclohexylmethyl ester 

Relevant academic research and scientific papers

Butyrophenones as hypotensive agents. Derivatives of 4 aryl 4 (hydroxymethyl)cyclohexylamine

The preparation of butyrophenone derivatives of 4 aryl 4 (hydroxymethyl) cyclohex 1 ylamines starting from the corresponding 4 cyano 4 phenylcyclohexan 1 ones is described. Substitution was varied in both rings; both isomers of 4 phenyl 4 (hydroxymethyl)cyclohex 1 ylamine were characterized. Those derivatives which carried p fluoro substitution on the butyrophenone exhibited hypotensive activity in the rat with diminished CNS activity compared to compounds lacking the hydroxymethyl group. The effect of substitution on the 4 aryl ring is discussed.