753450-40-7Relevant academic research and scientific papers
5-Lipoxygenase inhibitors with histamine H1 receptor antagonist activity
Lewis, Timothy A.,Bayless, Lynn,Eckman, Joseph B.,Ellis, James L.,Grewal, Gurmit,Libertine, Lyn,Nicolas, Jean Marie,Scannell, Ralph T.,Wels, Bruce F.,Wenberg, Karen,Wypij, Donna M.
, p. 2265 - 2268 (2007/10/03)
A series of novel compounds with both 5-lipoxygenase (5-LO) inhibitory and histamine H1 receptor antagonist activity were designed for the treatment of asthma. These dual-function compounds were made by connecting 5-LO and H1 pharmacophores,N-hydroxyureas and benzhydryl piperazines, respectively. A range of in vitro activities was observed, with the furan analog 10 demonstrating both activities in an animal model. The activities observed were compared to single-function drugs.
