753455-99-1

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 608-25-3 2-methylbenzene-1,3-diol 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 753456-06-3 7-acetoxy-2-amino-8-methyl-4-(4-chlorophenyl)-4H-chromene-3-carbonitrile 

Downstream Products

• 753456-06-3 7-acetoxy-2-amino-8-methyl-4-(4-chlorophenyl)-4H-chromene-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis and biological evaluation of new chromenes and chromeno[2,3-d] pyrimidines

A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradi

Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions

Abstract: The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract: Various aldehydes, malononitrile and activated phenols could be converted to thecorresponding 2-amino-4H-chromenes with good to excellent isolated yields underthe catalysis of choline acetate at room temperature. [Figure not available: see fulltext.]

Choline hydroxide promoted 2-amino-3-nitrile-7-hydroxyl-4H-chromene derivative one-pot synthesis method

The invention discloses a choline hydroxide promoted 2-amino-3-nitrile-7-hydroxyl-4H-chromene derivative one-pot synthesis method. Reaction substrates including a phenol compound, an aromatic aldehydecompound and malononitrile and a catalyst namely cholin

Method for preparing 2-amino-4H-chromene derivative by one-pot method promoted by hydrogen bond functionalized ionic liquid

The invention discloses a method for preparing a 2-amino-4H-chromene derivative by one-pot method promoted by a hydrogen bond functionalized ionic liquid. According to the method, a phenol compound, an aromatic aldehyde compound and malononitrile are used

Synthesis of hydroxyquinoline derivatives, amino-hydroxychromene, aminocoumarin and their anti-bacterial activities

Some new diaminochromenes (3a-f, 7a-c, and 10), 7-amino-4-aryl-coumarins (8a,b), 7-hydroxy-4-aryl-1,2-dihydroquinolines (9a-c) and 2-amino-7-hydroxy-4- (4-chlorophenyl)-4H-chromenes (16a-d) were synthesized via Michael addition of different substituted am