753478-48-7

Usage

Abbreviation

AMPC

Functional Groups

2-amino-1-methyl group
Carbonitrile group

Role in Synthesis

Building block in pharmaceutical and agrochemical synthesis
Reagent in organic synthesis for forming carbon-carbon and carbon-nitrogen bonds

Physical Properties

Appearance: Pale yellow solid
State at Room Temperature: Solid
Molecular Weight: 121.14 g/mol

Biological Importance

Vital intermediate in the production of biologically active compounds

Upstream product

• 122-07-6 N-(methyl)aminoacetaldehyde dimethyl acetal 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

1,4-DICARBONYL-PIPERIDYL DERIVATIVES

Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Facile synthesis of 1-substituted 2-amino-3-cyanopyrroles: New synthetic precursors for 5,6-unsubstituted pyrrolo[2,3-d]pyrimidines

(Equation Presented) 1-Benzyl-3-cyanopyrrole-2-carbonyl azide (5) underwent a Curtius rearrangement followed by quenching with alcohols to form the corresponding carbamates (6a-c). The carbamates 6a,b were unblocked to give the desired 2-amino-1-benzyl-3-cyanopyrrole (1a). A more facile procedure was subsequently developed for the synthesis of 1-substituted 2-amino-3- cyanopyrroles. N-Substituted aminoacetaldehyde dimethyl acetals (7a-c) were condensed with malononitrile in the presence of p-toluenesulfonic acid monohydrate to afford the corresponding 1-substituted 2-amino-3-cyanopyrroles (1a-c).