753483-50-0Relevant academic research and scientific papers
Diaminopyrimidine and diaminopyridine 5-HT7 ligands
Denhart, Derek J.,Purandare, Ashok V.,Catt, John D.,Dalton King,Gao, Aiming,Deskus, Jeffrey A.,Poss, Michael A.,Stark, Arlene D.,Torrente, John R.,Johnson, Graham,Mattson, Ronald J.
, p. 4249 - 4252 (2004)
The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT7 receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT7 receptor. The 5-HT7 binding affinities of different regioisomers show clearly the structure-activity relationship with position of ring nitrogens.
