753483-51-1Relevant academic research and scientific papers
IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS
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Page/Page column 123-124, (2011/07/09)
New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Imidazopyridine derivatives as JAK inhibitors
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Paragraph 0188; 0189, (2013/03/26)
New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Diaminopyrimidine and diaminopyridine 5-HT7 ligands
Denhart, Derek J.,Purandare, Ashok V.,Catt, John D.,Dalton King,Gao, Aiming,Deskus, Jeffrey A.,Poss, Michael A.,Stark, Arlene D.,Torrente, John R.,Johnson, Graham,Mattson, Ronald J.
, p. 4249 - 4252 (2007/10/03)
The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT7 receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT7 receptor. The 5-HT7 binding affinities of different regioisomers show clearly the structure-activity relationship with position of ring nitrogens.
