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753500-56-0

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753500-56-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 753500-56-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,3,5,0 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 753500-56:
(8*7)+(7*5)+(6*3)+(5*5)+(4*0)+(3*0)+(2*5)+(1*6)=150
150 % 10 = 0
So 753500-56-0 is a valid CAS Registry Number.

753500-56-0Downstream Products

753500-56-0Relevant articles and documents

Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors

Shao, Bin,Victory, Sam,Ilyin, Victor I.,Goehring, R. Richard,Sun, Qun,Hogenkamp, Derk,Hodges, Diane D.,Islam, Khondaker,Sha, Deyou,Zhang, Chongwu,Nguyen, Phong,Robledo, Silvia,Sakellaropoulos, George,Carter, Richard B.

, p. 4277 - 4285 (2004)

In the search for more efficacious drugs to treat neuropathic pain states, a series of phenoxyphenyl pyridines was designed based on 4-(4-flurophenoxy) benzaldehyde semicarbazone. Through variation of the substituents on the pyridine ring, several potent state-dependent sodium channel inhibitors were identified. From these compounds, 23 dose dependently reversed tactile allodynia in the Chung model of neuropathic pain. Administered orally at 10 mg/kg the level of reversal was ca. 50%, comparable to the effect of carbamazepine administered orally at 100 mg/kg.

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