753500-56-0Relevant articles and documents
Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors
Shao, Bin,Victory, Sam,Ilyin, Victor I.,Goehring, R. Richard,Sun, Qun,Hogenkamp, Derk,Hodges, Diane D.,Islam, Khondaker,Sha, Deyou,Zhang, Chongwu,Nguyen, Phong,Robledo, Silvia,Sakellaropoulos, George,Carter, Richard B.
, p. 4277 - 4285 (2004)
In the search for more efficacious drugs to treat neuropathic pain states, a series of phenoxyphenyl pyridines was designed based on 4-(4-flurophenoxy) benzaldehyde semicarbazone. Through variation of the substituents on the pyridine ring, several potent state-dependent sodium channel inhibitors were identified. From these compounds, 23 dose dependently reversed tactile allodynia in the Chung model of neuropathic pain. Administered orally at 10 mg/kg the level of reversal was ca. 50%, comparable to the effect of carbamazepine administered orally at 100 mg/kg.
