75353-77-4

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 69, p. 1565, 2004 DOI: 10.1021/jo030070z

InChI:InChI=1/C10H8N2O2/c1-7-10(12(13)14)6-8-4-2-3-5-9(8)11-7/h2-6H,1H3

Upstream product

• 10230-68-9 1-nitro-2-propanone 
• 529-23-7 o-aminobenzaldehyde 
• 17082-05-2 (E)-1-nitroprop-1-ene 
• 75-52-5 nitromethane 
• 13493-47-5 N-(2-formylphenyl)acetamide 

Downstream Products

• 1421348-43-7 C₂₅H₂₉N₃O₃ 
• 1421349-22-5 methyl 3-(4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzamido)propanoate 
• 1421349-21-4 4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzoic acid 
• 1421349-20-3 ethyl 4-(3-methyl-1-(2-methylquinolin-3-ylamino)butyl)benzoate 

Relevant academic research and scientific papers

A microwave-assisted facile one-pot synthesis of annelated pyridines from β-formyl enamides via henry reaction

The base-catalysed solid phase condensation of β-formyl enamides with nitromethane under microwave irradiation afforded a novel one-pot synthesis of pyridines via Henry reaction.

An Investigation of the Reaction of 2-Aminobenzaldehyde Derivatives with Conjugated Nitro-olefins: An Easy and Efficient Synthesis of 3-Nitro-1,2-dihydroquinolines and 3-Nitroquinolines

2-Aryl-3-nitro-1,2-dihydroquinolines 3 were prepared from the reaction of β-nitrostyrenes 2 and 2-aminobenzaldehyde 1 in the presence of DABCO. Not only β-nitrostyrenes but other alkyl nitro olefins also can be used in this reaction as well. When DDQ or silica gel was added to a solution of 3-nitro-1,2-dihydroquinolines 3, 3-nitro-2-substituted-quinolines 4 were obtained. When 2-aminobenzaldehyde derivatives 7 and 12 were reacted with β-nitrostyrenes 2, unique rearrangement products were produced.