75363-38-1Relevant academic research and scientific papers
NMR and x-ray conformational study of artemisiifolin and three other related germacranolides
Jimeno, Maria L.,Apreda-Rojas, Maria Del Carmen,Cano, Felix H.,Rodriguez, Benjamin
, p. 474 - 483 (2007/10/03)
From an acetone extract of Staehelina dubia, large quantities of the previously known germacranolide artemisiifolin were isolated. The conformations of the 10-membered germacra-1(10)E,4Z-diene ring system of this compound and those of its derivatives 11,13-dihydroartemisiifolin, isabelin and 6α-hydroxy-15-oxogermacra-1(10)E,4Z,11(13)-trien-12,8α-olide were studied by NMR spectroscopic methods. Low-energy conformations were obtained by quantum mechanical calculations. An x-ray diffraction analysis of artemisiifolin established that, in the crystalline state, it possesses a unique conformation that corresponds to the majority one existing in acetone-d6 solution. Copyright
