75397-66-9

Upstream product

• 83304-16-9 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide 
• 622-24-2 2-phenylethyl chloride 
• 104-47-2 p-methoxybenzylnitrile 
• 100-46-9 benzylamine 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 5153-67-3 nitrostyrene 
• 64-04-0 phenethylamine 

Downstream Products

• 58021-72-0 (isoquinolin-1-yl)(4-methoxyphenyl)methanone 
• 77671-13-7 1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisochinolin 

Relevant academic research and scientific papers

Synthesis and Photo-oxygenation of Some Substituted 1-Benzyl-3,4-dihydroisoquinolines. Mechanism of Enamine Photo-oxygenation

The synthesis of a series of substituted 1-benzyl-3,4-dihydroisoquinolines by Bischler-Napieralski cyclization is described.Competitive methylene blue sensitized photo-oxygenation experiments allowed the determination of relative rates of photo-oxygenation of 1-benzyl-3,4-dihydroisoquinolines.Substituents were shown to affect both the equilibrium concentration of the tautomeric enamine and the overall photo-oxygenation rate.After correcting for differences in enamine concentration, the relative rate data provided a diagnostic probe of the reaction mechanism, which involves transfer of charge in the rate-limiting step.

REGIOPSPECIFIC OXIDATION OF SUBSTITUTED 1-BENZYL-3,4-DIHYDROISOQUINOLINES USING SINGLET OXYGEN

Singlet oxygen regiospecifically oxidizes 1-benzyl-3,4-dihydroisoquinoline to 1-benzoyl-3,4-dihydroisoquinoline.Mechanistic studies do not distinguish between a dioxetane or the alternative zwitterionic peroxide intermediate.