75405-46-8Relevant academic research and scientific papers
Oxa-enediynes: Probing the electronic and stereoelectronic contributions to the bergman cycloaromatization
Jones, Graham B.,Wright, Justin M.,Hynd, George,Wyatt, Justin K.,Warner, Philip M.,Huber, Robert S.,Li, Aiwen,Kilgore, Michael W.,Sticca, Robert P.,Pollenz, Richard S.
, p. 5727 - 5732 (2007/10/03)
Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).
Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne
Jones, Graham B.,Kilgore, Michael W.,Pollenz, Richard S.,Li, Aiwen,Mathews, Jude E.,Wright, Justin M.,Huber, Robert S.,Tate, Patricia L.,Price, Thomas L.,Sticca, Robert P.
, p. 1971 - 1976 (2007/10/03)
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
