75416-71-6Relevant academic research and scientific papers
[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues
Hong, Yong Rae,Kim, Hyun Tae,Lee, Seung-Chul,Ro, Seonggu,Cho, Joong Myung,Kim, In Su,Jung, Young Hoon
supporting information, p. 5953 - 5957 (2013/10/22)
A new series of PHD (HIF prolyl 4-hydroxylase) inhibitors was designed based on the X-ray co-crystal structure of FG-2216. Using a lead generation process, a series of [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)- amino]-acetic acid derivatives was developed as potent PHD2 inhibitors. This class of compounds also showed the ability to stabilize HIF-α, to stimulate EPO secretion in in vitro studies, and to increase hematocrit, red blood cell count, and hemoglobin levels in an animal efficacy study.
PHOTOCYCLIZATION OF METHYL 2-ARYLTHIO- AND 2-ARYLOXY-ACETOACETATES A FACILE SYNTHESIS OF BENZOHETEROCYCLES
Sasaki, Tadashi,Hayakawa, Kenji,Ban, Hiroshi
, p. 85 - 91 (2007/10/02)
A series of methyl 2-arylthio- (2) and 2-aryloxy-acetoacetates (3) have been prepared and their tautomeric equilibria have been examined by 1H NMR spectroscopy.S-substitution at the α-position results in an increase of enol tautomer over 90percent, while
PHOTOCYCLIZATION OF METHYL 2-ARYLTHIOACETOACETATES A FACILE SYNTHESIS OF BENZOTHIOPHENES
Sasaki, Tadashi,Hayakawa, Kenji
, p. 1525 - 1526 (2007/10/02)
A series of methyl 2-arylthioacetoacetates was irradiated in a benzene-methanol solution to give benzothiophenes in satisfactory yields.
