75419-20-4

Upstream product

• 125590-94-5 (2R)-4-Iodobutan-2-ol 
• 603-35-0 triphenylphosphine 
• 19493-09-5 Methylenetriphenylphosphorane 
• 15448-47-2 (R)-propylene oxide 
• 946133-91-1 (3R)-1-iodo-3-triethylsilyloxy-butane 

Downstream Products

• 1166898-09-4 (8S,20S)-des-A,B-8-benzoyloxy-20-[(4'R)-hydroxy-pent-(1'E)-en-yl]-pregnane 
• 946133-92-2 (8S,20R)-des-A,B-8-benzoyloxy-20-[(4'R)-hydroxy-pent-(1'E)-en-yl]-pregnane 
• 75351-39-2 (R)-4-(Triphenyl-λ⁵-phosphanylidene)-butan-2-ol 

Relevant academic research and scientific papers

2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses

This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities evidencing use as an anti-cancer agent and for the treatm

2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs

This invention discloses 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20R,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity

2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs

This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity

Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription

Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at

2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs

This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin

VITAMIN D ANALOG - RAK, METHODS AND USES THEREOF

Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 ca

An efficient synthesis of (R)-(+)-recifeiolide and related macrolides by using enantiomerically pure (R)-(-)-5-methyl-2,2,2-triphenyl-l,2λ5- oxaphospholane

E-(R)-(+)-8-Dodece- 11-olide, which is known as recifeiolide, was synthesized by a six-step reaction starting from (R)-(+)-propene oxide in a total yield of 53 %. The key step of this synthesis is the preparation of (R)-(-)-methyl 11-hydroxy-8-dodecenate using (R)-(-)-5-methyl-2,2,2- triphenyl-1,2λ5-oxaphospholane. By using this method, enantiomerically pure 13- and 14-membered macrolides were also synthesized.

STEREOSPECIFIC TOTAL SYNTHESIS AND ABSOLUTE CONFIGURATION OF A MACROCYCLIC LACTONE ANTIBIOTIC, A26771B

The total synthesis of a sixteen-membered macrocyclic lactone antibiotic, A26771B and its absolute configuration are described by using D-glucose as a chiral source.