75421-11-3Relevant academic research and scientific papers
A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors
Kim, Minkyoung,Gajulapati, Kondaji,Kim, Chorong,Jung, Hwa Young,Goo, Jail,Lee, Kyeong,Kaur, Navneet,Kang, Hyo Jin,Chung, Sang J.,Choi, Yongseok
supporting information, p. 11443 - 11445 (2013/01/15)
A variety of diazepinone derivatives were prepared from α-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3, 4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (Ki = 145.97 ± 4.87 nM) against human cytidine deaminase.
Cyclic Urea Nucleosides. Cytidine Deaminase Activity as a Function of Aglycon Ring Size
Liu, Paul S.,Marquez, Victor E.,Driscoll, John S.,Fuller, Richard W.,McCormack, John J.
, p. 662 - 666 (2007/10/02)
Five β-D-ribofuranosyl cyclic urea nucleosides (14-18), ranging in size from five to eight membered, were synthesized and evaluated as cytidine deaminase (CDA) inhibitors.The precursor protected nucleosides (9-13) were prepared by a condensation procedure
Seven-membered ring compounds as inhibitors of cytidine deaminase
-
, (2008/06/13)
Seven-membered heterocyclic nucleosides used to inhibit the deamination enzyme responsible for the inactivation of arabinosylcytosine (ara--C). Preferred nucleosides containing a seven-member aglycone are as follows: STR1 Preferred aglycones are as follow
Synthesis of 1,3-Diazepin-2-one Nucleosides as Transition-State Inhibitors of Cytidine Deaminase. 2
Liu, Paul S.,Marquez, Victor E.,Kelley, James A.,Driscoll, John S.
, p. 5225 - 5227 (2007/10/02)
Syntheses of the novel seven-membered-ring (+-)-5-hydroxy-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one (8) and its 1-β-D-ribofuranosyl nucleosides 4a and 4b have been accomplished by adaption of the transpositional allylic oxidation procedure following the electrophilic addition of ArSeOH to the corresponding starting olefins 5 and 11.
