754224-82-3Relevant academic research and scientific papers
An investigation into the synthesis of some molecules related to methyl acarviosin
McDonough, Matthew J.,Stick, Robert V.,Tilbrook, D. Matthew G.,Watts, Andrew G.
, p. 233 - 241 (2007/10/03)
Methyl acarviosin is an impressive inhibitor of some glycoside hydrolases that process substrates containing α-D-glucosidic linkages. In an attempt to provide putative inhibitors for enzymes that process β-D-glucosidic linkages, we report an improved synthesis of a hydroxylated 'methyl β-acarviosin' and our efforts towards various deoxygenated versions of methyl β-acarviosin. As well, the synthesis of a 1,3-linked variant of methyl β-acarviosin is reported, together with an unsuccessful 'tether' approach to construct the crucial nitrogen linkage in the acarviosins.
