754235-83-1

Upstream product

• 1021539-25-2 (3R,3aS)-3-ethynyl-3-hydroxy-3a-methyl-6-oxo-2,3,3a,4,5,6-hexahydro-1H-indene-5-carbaldehyde 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 1021539-23-0 (1S,7aS)-1-hydroxy-7a-methyl-1-[(trimethylsilyl)ethynyl]-1,2,3,6,7,7a-hexahydro-5H-inden-5-one 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 1021539-36-5 (4aS,5R)-5-((2-aminophenyl)ethynyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1021539-32-1 1-(2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)phenyl)ethanone 
• 1021539-39-8 (4aS,5R)-1-(4-fluorophenyl)-5-((2-hydroxyinophenyl)ethynyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1021539-44-5 methyl (2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)phenyl)acetate 
• 1021539-40-1 (4aS,5R)-1-(4-fluorophenyl)-4a-methyl-5-((2-(methylsulfonyl)phenyl)ethynyl)-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1021539-26-3 methyl 2-{[(4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl]ethynyl}benzoate 
• 1021539-49-0 methyl 5-fluoro-2-{[(4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl]ethynyl}benzoate 
• 1021539-41-2 2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)benzonitrile 
• 1021539-43-4 2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)benzenesulfonamide 
• 1021539-61-6 C₂₆H₂₁F₂N₃O₂ 
• 1021539-47-8 2-(2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)phenyl)acetamide 
• 1021539-52-5 methyl (2-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)phenyl)hydroxyacetate 
• 1021539-55-8 ethyl (2-fluoro-6-(((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethynyl)phenyl)acetate 
• 1021539-30-9 (4aS,5R)-5-(2-(1-aminocyclopropylphenyl)ethynyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 

Relevant academic research and scientific papers

Discovery of selective glucocorticoid receptor modulator MK-5932

A series of partial agonists of the Glucocorticoid Receptor were prepared targeting reduced transactivation activity, while maintaining significant transrepression activity. Incorporation of an ortho-aryl amide produced compounds with the desired in vitro

HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS

The present invention encompasses compounds of Formula (I): or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.

PROCESS FOR MAKING GLUCOCORTICOID RECEPTOR LIGANDS

The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases.

2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS

The present invention is directed to 2- [l-phenyl-5 -hydroxy or methoxy-4alpha- methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives of formula I (I) as glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflamma