75426-51-6

Usage

Chemical compound

3-[4-(2-chlorophenyl)-piperazin-1-yl]-propionitrile

Structure

Consists of a piperazine ring with a propionitrile side chain and a 2-chlorophenyl group

Use

Commonly used in pharmaceutical research and drug development

Effects

Potential behavioral effects on the central nervous system

Potential treatment

May be used in the treatment of various psychiatric disorders

Mechanism of action

Structure suggests it could act as a serotonin receptor agonist

Potential applications

Development of new medications for mood and anxiety disorders

Study

Applications in the study of the serotonin system and its role in psychiatric conditions

Future research

Needed to fully understand the potential uses and effects of the compound

Upstream product

• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 107-13-1 acrylonitrile 
• 95-51-2 o-chloroaniline 

Downstream Products

• 55931-64-1 3-[4-(2-chlorophenyl)piperazin-1-yl]propylamine 
• 740831-41-8 1-(2-chlorophenyl)-4-[2-(1H-tetrazol-5-yl)-ethyl]-piperazine 
• 79323-05-0 1-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-4-(4-methoxy-phenyl)-piperidine-2,6-dione 
• 90619-45-7 3-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-1,8,8-trimethyl-3-aza-bicyclo[3.2.1]octane-2,4-dione; hydrochloride 
• 90619-38-8 2-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 102589-44-6 N-{3-[4-(2-chloro-phenyl)-piperazino]-propyl}-acetamide 

Relevant academic research and scientific papers

Optically active antifungal azoles: Synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl} -tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol

A series of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]- ethyl}-tetrazol-2-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol (11a-n) and (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl} -tetrazole-1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol (12a-n) has been synthesized. The antifungal activity of compounds was evaluated by in vitro agar diffusion and broth dilution assay. Compounds 11d and its positional isomer 12d having 3-trifluoromethyl substitution on the phenyl ring of piperazine demonstrated significant antifungal activity against variety of fungal cultures (Candida spp. C. neoformans and Aspergillus spp.). The compound 12d showed MIC value of 0.12μg/mL for C. albicans, C. albicans V-01-191A-261 (resistant strain); 0.25μg/mL for C. tropicalis, C. parapsilosis ATCC 22019 and C. krusei and MIC value of 0.5μg/mL for C. glabrata, C. krusei ATCC 6258, which is comparable to itraconazole and better than fluconazole. Further, compound 11d showed significant activity (MIC; 0.25-0.5μg/mL) against Candida spp. and strong anticryptococcal activity (MIC; 0.25μg/mL) against C. neoformans.