7543-22-8

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone is utilized as a key intermediate in the synthesis of complex organic molecules, particularly in the development of pharmaceutical drugs. Its unique structure allows for the exploration of its potential biological activities and pharmacological properties, making it a valuable compound in drug discovery and design.
Used in the Synthesis of Pharmaceutical Drugs:
As a building block in the creation of pharmaceutical drugs, 2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone plays a crucial role in the development of new therapeutic agents. Its incorporation into drug molecules can enhance their efficacy, selectivity, and pharmacokinetic properties, leading to improved treatments for various diseases and conditions.
Used in Agrochemicals:
2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone also finds application in the agrochemical industry, where it serves as an intermediate in the synthesis of various agrochemical products. Its use in this field contributes to the development of effective and environmentally friendly solutions for crop protection and pest management.
Used in Industrial Processes and Scientific Research:
Beyond its applications in the pharmaceutical and agrochemical industries, 2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone may also be employed in other industrial processes and scientific research endeavors. Its unique chemical properties and potential for further modification make it a versatile compound for exploration in various scientific and technological fields.

Upstream product

• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 2524-52-9 ethyl-2-picolinate 

Downstream Products

• 396129-53-6 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline 

Relevant academic research and scientific papers

Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors

Optimization of the screening hit 1 led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5. Compounds 15 and 19, whic

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

We have expanded our previously reported series of pyrazole-based inhibitors of the TGF-β type I receptor kinase domain (TβR-I) to now include new 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole analogues. Limited examination of the SAR of this new series in both e

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Pyrazole-based inhibitors of the transforming growth factor-β type I receptor kinase domain (TβR-I) are described. Examination of the SAR in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differing selectivity versus p38 MAP kinase. A common binding mode at the active site has been established by successful cocrystallization and X-ray analysis of potent inhibitors with the TβR-I receptor kinase domain.