75447-68-6Relevant academic research and scientific papers
A practical synthesis of chloromethyl esters from acid chlorides and trioxane or paraformaldehyde promoted by zirconium tetrachloride
Mudryk, Boguslaw,Rajaraman, Shanthi,Soundararajan, Nachimuthu
, p. 6317 - 6318 (2007/10/03)
A practical synthesis of chloromethyl esters from acid chlorides and trioxane or paraformaldehyde using zirconium tetrachloride as the Lewis acid has been demonstrated. The new procedure is highly chemoselective and applies to a variety of acid chlorides.
Quantitative Evaluation of the Reactivity of Alkylating Agents
Bodor, Nicholas,Kaminski, James J.,Worley, S. D.,Gerson, Steven H.
, p. 758 - 763 (2007/10/02)
A sensitive and reproducible method for quantitative evaluation of the relative reactivities of alkylating agents was developed, based on competitive alkylation.The method is superior to the known calorimetric methods.The reactivities of the agents could also be correlated with the 13C chemical shifts of the α-methylene.The method was successfully applied for the ranking of "soft" alkylating agents of low reactivity. - Keywords: Alkylating Agents, Soft Drugs, NMR Spectra, Competitive Alkylation, Soft Quaternary Salts
