75448-69-0

Usage

General Description

Ethyl 3-(hydroxymethyl)-1H-pyrrole-2-carboxylate, also known as ethyl levulinate, is a chemical compound with the molecular formula C7H9NO3. It is a derivative of levulinic acid and is commonly used as a flavoring agent in the food and beverage industry. Ethyl levulinate is also used as a precursor in the production of biofuels and as a solvent in various industrial applications. It is a colorless, viscous liquid with a sweet, fruity odor and is generally considered to be safe for human consumption when used in accordance with food safety regulations. Additionally, it has potential applications in the pharmaceutical and cosmetic industries due to its versatile chemical properties.

Upstream product

• 36131-43-8 ethyl 3-formyl-1H-pyrrole-2-carboxylate 
• 7126-44-5 3-Cyan-2-pyrrolcarbonsaeure-ethylester 
• 2999-46-4 Ethyl isocyanoacetate 
• 107-19-7 propargyl alcohol 

Downstream Products

• 36131-43-8 ethyl 3-formyl-1H-pyrrole-2-carboxylate 
• 1448531-49-4 diethyl 1-(2-nitrophenyl)pyrrole-2,3-dicarboxylate 
• 25472-60-0 1H-Pyrrol-2,3-dicarbonsaeure-diethylester 
• 75448-71-4 3-Benzyloxymethyl-2-pyrrolcarbonsaeure-ethylester 

Relevant academic research and scientific papers

Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells

Acute leukemia is a hematological malignancy with high incidence and recurrence rates and is characterized by an accumulation of blasts in bone marrow due to proliferation of immature lymphoid or myeloid cells associated with a blockade of differentiation. The heterogeneity of leukemia led us to look for new specific molecules for leukemia subtypes or for therapy-resistant cases. Among heterocyclic derivatives that attracted attention due to their wide range of biological activities, we focused our interest on the pyrrolo[1,2-a]quinoxaline heterocyclic framework that has been previously identified as an interesting scaffold for antiproliferative activities against various human cancer cell lines. In this work, new ethyl 4-[4-(4-substituted piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate derivatives (1 a–o) were designed, synthesized, and evaluated against five different leukemia cell lines, including Jurkat and U266 (lymphoid cell lines) and K562, U937, and HL60 (myeloid cell lines), as well as on normal human peripheral blood mononuclear cells (PBMCs). This new pyrrolo[1,2-a]quinoxaline series showed interesting cytotoxic potential against all tested leukemia cell lines. In particular, pyrroloquinoxalines 1 a and 1 m,n seem to be interesting due to their high activity against leukemia and their low activity against normal hematopoietic cells, leading to a high index of selectivity.

Silver-catalyzed isocyanide-alkyne cycloaddition: A general and practical method to oligosubstituted pyrroles

Ag2CO3 is the key: The transition-metal-catalyzed cycloaddition of isocyanides and unactivated terminal alkynes has been realized with Ag2CO3 as a unique and robust catalyst (see scheme). The protocol is highly

Synthesis of pyrroles by click reaction: Silver-catalyzed cycloaddition of terminal alkynes with isocyanides

Just click with silver: Pyrroles are prepared by the co-cyclization of terminal alkynes and isocyanides in a silver-catalyzed click reaction. This route represents an extremely simple, efficient, and atom-economic approach to substituted pyrroles in good yields with high selectivity, thus complementing the click method for the rapid formation of multifunctional heterocycles. Copyright

Synthesis of 5,7a-Didehydroheliotridin-3-one, the Basis Compound of a New Class of Pyrrolizidine Alkaloids

Starting with the disubstituted pyrrole derivative 4c the title compound 12b was synthesized in three steps in 40percent overall yield using the Bestmann reaction with (triphenylphosphoranylidene)ketene (6).