75456-79-0Relevant academic research and scientific papers
ACTION DE L'ACIDE FLUORHYDRIQUE SUR LES AZIRINES: SYNTHESE D'α-FLUOROCETONES ET DE DIFLUOROAMINES - ETUDE DE L'ORIENTATION DE LA REACTION
Alvernhe, Gerard,Lacombe, Sylvie,Laurent, Andre
, p. 1437 - 1440 (2007/10/02)
Addition of Olah's reagent in benzene or methylene chloride to azirines leads to the formation of difluoroamines or α-fluoroketones.This reaction has been applied to the synthesis of 17 α-fluoropregnolone.The formation of fluoroketone proceeds via a cationic intermediate.Yield is improved when using a more nucleophilic fluorinating reagent obtained by addition of triethylamine to Olah's reagent.
