75458-75-2Relevant academic research and scientific papers
2-(2-Amino-2-methylpropyl)phenols by C-C-Linkage of 2-Hydroxybenzyl Alcohols with 2-Nitropropane Anions
Diery, Helmut,Renger, Bernd
, p. 1239 - 1251 (2007/10/02)
The 2-hydroxybenzyl alcohols 1, 6, 8a, and 8e can be converted into the 2-(2-methyl-2-nitropropyl)-phenols 2, 7, and 9 by a SRN1-reaction with the sodium salt of 2-nitropropane.Catalytic hydrogenation yields the amines 3 and 10.The consequent reactions - leading to the quaternary salts 13 and 14 and as to the addition-compounds 15 and 16 - are negatively influenced by the strong steric shielding of the amino groups.
