755002-40-5Relevant academic research and scientific papers
Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue
Shimazawa, Rumiko,Gochomori, Mika,Shirai, Ryuichi
, p. 4339 - 4342 (2007/10/03)
Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D3, and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC50=0.7-24.5μM).
