755026-53-0Relevant articles and documents
BENZODIAZEPINONES AS FAK INHIBITORS FOR TREATMENT OF CANCER
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Page/Page column 63, (2012/04/23)
Disclosed are compounds which inhibit the activity of focal adhesion kinase, compositions containing the compounds, and methods of treating diseases during which focal adhesion kinase is expressed.
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1, 4]diazepin-11-one-based potent and selective Chk-1 inhibitors
Wang, Le,Sullivan, Gerard M.,Hexamer, Laura A.,Hasvold, Lisa A.,Thalji, Reema,Przytulinska, Magdalena,Tao, Zhi-Fu,Li, Gaoquan,Chen, Zehan,Xiao, Zhan,Gu, Wen-Zhen,Xue, John,Bui, Mai-Ha,Merta, Philip,Kovar, Peter,Bouska, Jennifer J.,Zhang, Haiying,Park, Chang,Stewart, Kent D.,Sham, Hing L.,Sowin, Thomas J.,Rosenberg, Saul H.,Lin, Nan-Horng
, p. 4162 - 4176 (2008/02/13)
A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the
HETEROCYCLIC KINASE INHIBITORS
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Page 60, (2010/02/08)
Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.