755026-96-1Relevant articles and documents
HETEROARYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
-
Paragraph 0131-0134, (2021/12/07)
The present invention relates to a heteroaryl derivative and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient, and a compound according to an aspect of the present invention, a stereoisomer
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS
-
Page/Page column 62; 63, (2021/02/05)
The present invention relates to compounds comprising an interleukin-1 receptor-associated kinase 1 (IRAK1) protein binding moiety and a Von Hippel-Lindau (VHL) E3 ubiquitin ligase binding moiety, and associated methods of use. The compounds are useful as modulators of targeted ubiquitination, especially with respect to IRAK1, which is degraded by the compounds according to the invention.
TYK2 INHIBITORS AND USES THEREOF
-
Paragraph 00754; 00755, (2018/05/15)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
TAU IMAGING PROBE
-
Paragraph 0462; 0463, (2013/09/12)
An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1, 4]diazepin-11-one-based potent and selective Chk-1 inhibitors
Wang, Le,Sullivan, Gerard M.,Hexamer, Laura A.,Hasvold, Lisa A.,Thalji, Reema,Przytulinska, Magdalena,Tao, Zhi-Fu,Li, Gaoquan,Chen, Zehan,Xiao, Zhan,Gu, Wen-Zhen,Xue, John,Bui, Mai-Ha,Merta, Philip,Kovar, Peter,Bouska, Jennifer J.,Zhang, Haiying,Park, Chang,Stewart, Kent D.,Sham, Hing L.,Sowin, Thomas J.,Rosenberg, Saul H.,Lin, Nan-Horng
, p. 4162 - 4176 (2008/02/13)
A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the
HETEROCYCLIC KINASE INHIBITORS
-
Page 178-179, (2010/02/08)
Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.