75508-74-6

Upstream product

• 106-43-4 para-chlorotoluene 
• 108-24-7 acetic anhydride 

Downstream Products

• 89-59-8 4-chloro-2-nitrotoluene 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 86297-37-2 5-chloro-2-methylphenyl acetate 
• 106-43-4 para-chlorotoluene 
• 119-33-5 4-methyl-2-nitrophenol 
• 5306-98-9 5-chloro-2-methyl-phenol 

Relevant academic research and scientific papers

ipso Nitration. XXVIII. Nitration of 4-substituted toluenes: 1,2 adducts

Nitration of 4-acetamido, 4-chloro, and 4-methoxy-toluene in acetic anhydride gives in each case a cis 1,2 nitronium acetate adduct in adition to the nitro substitution product(s).Nitration of 4-fluorotoluene gives a pair of diastereomeric 1,4 nitronium acetate adducts and the cis 1,2 adduct.

ipso-Nitration: Formation of Nitronium Acetate Adducts in the Nitration of p-Acetamido-, p-Halogeno-, and p-Methoxy-toluenes, and α-p-Tolyloxyisobutyric acid

Low-temperature nitration of the title compounds in acetic anhydride gives 1,2-nitronium acetate adducts, except p-fluorotoluene which gives both 1,2 and 1,4 adducts and α-p-tolyloxyisobutyric acid which gives a spiro adduct.