75516-80-2Relevant academic research and scientific papers
Cycloaddition vs. Michael Addition in the Metal Halide/Amine-Induced Reactions of α-(Alkylideneamino) Esters with Electron-Deficient Olefins
Kanemasa, Shuji,Yoshioka, Manabu,Tsuge, Otohiko
, p. 869 - 874 (2007/10/02)
The lithiated intermediate derived from methyl 2-(benzylideneamino)propanoate and lithium bromide/triethylamine undergoes cycloaddition and Michael addition with methyl acrylate. 1,3-Dipole character of the intermediate is suggested on the basis of the pr
X=Y-ZH Systems as Potential 1,3-Dipoles. Part 7. Stereochemistry of the Cycloaddition of Imines of α-Amino Acid Esters to Fumarate and Maleate Esters
Grigg, Ronald,Kemp, James,Warnock, William J.
, p. 2275 - 2284 (2007/10/02)
Aryl imines of α-amino acid esters undergo 1,3-dipolar cycloadditions with maleate and fumarate esters in quantitative yield when heated in boiling toluene to give mixtures of mainly two pyrrolidines.The major isomer in each case arises from cycloaddition
X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. THE STEREOCHEMISTRY AND REGIOCHEMISTRY OF CYCLOADDITION REACTIONS OF IMINES OF α-AMINO-ACID ESTERS.
Grigg, Ronald,Kemp, James
, p. 2461 - 2464 (2007/10/02)
The stereochemistry and regiochemistry of cycloadditions of α-amino acid ester imines is dependent both on imine structure and on the reactivity of the dipolarophile.Phenylglycine imines undergo competing dipole stereomutation and cycloaddition with some dipolarophiles.
