75519-54-9Relevant academic research and scientific papers
New pyrazole-tethered Schiffs bases as ligands for the Suzuki reaction
Mukherjee, Anuradha,Sarkar, Amitabha
, p. 15 - 18 (2005)
Pyrazole-tethered Schiffs base ligands 2 promote Suzuki coupling of aryl bromides and chlorides with phenylboronic acid efficiently under mild conditions.
BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
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Page/Page column 88-89, (2011/06/25)
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, method
An efficient synthesis of radiolabelled SANT-1
Zhang, Yinsheng,Stolle, Wayne T.
scheme or table, p. 487 - 489 (2011/05/05)
SANT-1, (4-benzyl-N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-1- piperazinamine), is a reference compound and used for establishing a biological assay for the smoothened receptor (SMO). Preparation of radiolabelled material was needed for establishing radioligand protein/receptor binding studies. [ 3H]SANT-1 was prepared with a radiochemical purity of >95% (25 Ci/mmol) using direct Crabtree catalyzed T/H exchange method, while [ 14C]SANT-1 was synthesized at 98.2% radiochemical purity (54 mCi/mmol) using [14C]dimethylformamide. The details of the syntheses of radioactive labelled SANT-1 were presented. Copyright
Competitive Cyclisations of Singlet and Triplet Nitrenes. Part 8. The 1-(2-Nitrenophenyl)pyrazoles and Related Systems
Lindley, John M.,McRobbie, Ian M.,Meth-Cohn, Otto,Suschitzky, Hans
, p. 982 - 994 (2007/10/02)
The title nitrenes, derived by nitro-group deoxygenation with triethyl phosphite or by thermolysis or photolysis of the corresponding azide, have been studied.The effect of substituents (Cl, Br, OMe, NMe2, Me, CF3, and NO2) both meta and para to the nitrene has been examined as a determinant of the preferred mode of cyclisation to either a pyrazolobenzotriazole or a pyrazoloquinoxaline.Similarly, the role of solvents, sensitisers, and quenchers has been studied.Routes to the isomeric 1- and 2-(2-nitrophenyl)-4,5,6,7-tetrahydroindazoles have been defined and the literature corrected by studing the nitrene-mediated cyclisation of these products.The chemistry of the analogous 1-(2-carbenophenyl)- and the 1-(2-nitrenosulphonylphenyl)-3,5-dimethylpyrazoles has also been examined, the former giving 2-(3,5-dimethylpyrazol-1-yl)-benzaldazine and -benzyl alcohol while the latter gave products of intramolecular nitrene attack (a pyrazolobenzothiatriazine) and intermolecular reaction.Rationalisations for all the reaction pathways have been advanced.
