75524-08-2Relevant articles and documents
New chemical aspects of primidone metabolism
Lafont,Cave,Menager,Miocque
, p. 61 - 66 (2007/10/02)
Primidone is metabolized either into phenylethylmalondiamide or phenobarbital. 2-Hydroxyprimidone was synthesized and tested as a potential intermediate common to these two biodegradation pathways in dogs as well as in vitro. On the other hand, the mechanism of the formation of α-phenyl-γ-butyrolactone during intoxication was investigated and the role of precursor played by the phenobarbital generated in vivo was shown.