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Tris-(β-phenylethyl)telluronium bromide, also known as TPeTBr, is a chemical compound with the formula C18H19BrTe. It is a white crystalline solid that is soluble in organic solvents such as acetonitrile and dimethyl sulfoxide. TPeTBr is a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the biosynthesis of pyrimidine nucleotides. This enzyme is essential for the growth and survival of rapidly dividing cells, making TPeTBr a potential candidate for the development of anti-cancer and anti-proliferative drugs. The compound has been shown to exhibit significant cytotoxicity against various cancer cell lines, and its mechanism of action involves the inhibition of DHODH, leading to the depletion of pyrimidine nucleotides and subsequent cell death. TPeTBr's unique structure and selectivity for DHODH make it an interesting target for further research and development in the field of cancer therapeutics.

75529-06-5

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75529-06-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 75529-06-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,2 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 75529-06:
(7*7)+(6*5)+(5*5)+(4*2)+(3*9)+(2*0)+(1*6)=145
145 % 10 = 5
So 75529-06-5 is a valid CAS Registry Number.

75529-06-5Downstream Products

75529-06-5Relevant academic research and scientific papers

Mechanism of Thermal Decomposition of Tetra-aryltellurium Species

Glover, Stephen A.

, p. 1338 - 1344 (2007/10/02)

Tetra-aryltellurium species decompose upon heating giving good yields of diaryl tellurides and biphenyls.Radical-scavenging experiments show that phenyl radicals are not intermediates in the formation of biphenyls.In contrast, cross-over experiments give mixed biphenyls as well as mixed diaryl tellurides, but these are formed by a statistical redistribution of organic groups giving mixed tetra-aryltellurium species which decompose thermally in an indiscrimate fashion.

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