75530-61-9Relevant articles and documents
Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives
Ebiike, Hirosato,Maruyama, Kaori,Ozawa, Yumi,Yamazaki, Yukiyoshi,Achiwa, Kazuo
, p. 869 - 876 (2007/10/03)
Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot