EC 3.5.3.15, also known as peptidyl arginine deiminase (PAD), is an enzyme that catalyzes the conversion of arginine into citrulline. It plays a crucial role in various biological processes and has been the subject of research for its potential applications in medical and diagnostic fields.
75536-80-0
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Basic information
- Product Name: EC 3.5.3.15
- Synonyms: PROTEIN ARGININE IMINOHYDROLASE;PEPTIDYL ARGININE DEIMINASE;EC 3.5.3.15;peptidyl arginine deiminase from rabbit skeletal muscle
- CAS NO:75536-80-0
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /buffered aqueous glycerol solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: EC 3.5.3.15(CAS DataBase Reference)
- NIST Chemistry Reference: EC 3.5.3.15(75536-80-0)
- EPA Substance Registry System: EC 3.5.3.15(75536-80-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 1
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 75536-80-0(Hazardous Substances Data)
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75536-80-0 Usage
Uses
Used in Medical Research:EC 3.5.3.15 is used as a biomarker for the early diagnosis of rheumatoid arthritis. In a study, it was assessed as a promising novel biomarker to help identify this autoimmune disease in its early stages, potentially leading to better treatment outcomes for patients.
Used in Dental Research:
In the field of dentistry, EC 3.5.3.15 has been used to investigate the autopathogenic correlation between periodontitis and rheumatoid arthritis. This research aims to better understand the connection between oral health and overall health, and how periodontal disease may contribute to the development of rheumatoid arthritis.
Used in Pharmaceutical Development:
Although not explicitly mentioned in the provided materials, PAD enzymes like EC 3.5.3.15 could potentially be used in the development of new drugs targeting various diseases, including autoimmune and inflammatory conditions. Their role in protein citrullination, a post-translational modification, makes them an interesting target for therapeutic intervention.
Biochem/physiol Actions
Calcium is required for peptidylarginine deiminase activity in vitro.Check Digit Verification of cas no
The CAS Registry Mumber 75536-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,3 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.Calculate Digit Verification of CAS Registry Number 75536-80:
(7*7)+(6*5)+(5*5)+(4*3)+(3*6)+(2*8)+(1*0)=150
150 % 10 = 0
So 75536-80-0 is a valid CAS Registry Number.
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EC 3.5.3.15
