7555-15-9

Upstream product

• 5391-39-9 1-acetylimidazolidin-2-one 
• 608-31-1 2,6-Dichloroaniline 
• 825-43-4 2-oxo-imidazolidine-1-carboxylic acid ethyl ester 
• 55150-38-4 1-phenoxyacetyl-imidazolidin-2-one 
• 120-93-4 imidazolidone 
• 60-80-0 antipyrine 
• 103-80-0 phenylacetyl chloride 
• 54707-71-0 1-acetyl-2-(2,6-dichloro-anilino)-4,5-dihydro-1H-imidazole 

Relevant academic research and scientific papers

Imidazoline derivatives and the preparation thereof

A process for the preparation of 2-(substituted aryl)amino-2-imidazoline derivatives by reacting appropriate substituted aniline derivatives with 1-aroyl-imidazoline-2-ones in the presence of at least two mols of phosphorus oxychloride per mol of the aniline derivative and optionally hydrolyzing the resulting intermediate compound. Certain novel 2-dihaloarylamino-2-imidazoline derivatives with hypotensive action are also disclosed.

Process for the manufacture of 2-arylamino-2-imidazoline derivatives and their salts

A process for the preparation of the known and valuable 2-aryl-amino-2-imidazoline derivatives which comprises condensing an appropriately substituted aniline with a 1-acyl-imidazolidin-2-one to produce an intermediate compound which on neutralisation in an aqueous medium is converted into a N-acyl derivative of the 2-aryl-amino-2-imidazoline, and splitting the intermediate compound or the said N-acyl derivative to give the corresponding free arylamino-2-imidazoline derivative or a salt thereof.