7556-99-2 Usage
General Description
7-Chloroquinazoline is a chemical compound with the molecular formula C8H5ClN2. It is a heterocyclic compound containing a quinazoline ring with a chlorine atom attached to the 7th position. 7-chloroquinazoline has potential applications in the field of medicinal chemistry, as quinazoline derivatives have been studied for their pharmacological activities, including antitumor, antibacterial, and antifungal properties. Additionally, 7-Chloroquinazoline can be used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a valuable building block in the development of new compounds for pharmaceutical and agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 7556-99-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,5 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7556-99:
(6*7)+(5*5)+(4*5)+(3*6)+(2*9)+(1*9)=132
132 % 10 = 2
So 7556-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2/c9-7-2-1-6-4-10-5-11-8(6)3-7/h1-5H
7556-99-2Relevant articles and documents
A novel synthesis of quinazolines by cyclization of 1-(2-isocyanophenyl) alkylideneamines generated by the treatment of 2-(1-azidoalkyl)phenyl isocyanides with NaH
Ezaki, Kosuke,Kobayashi, Kazuhiro
, p. 822 - 829 (2014/07/07)
A new and efficient method for the synthesis of quinazolines has been developed. Thus, N-[2-(1-azidoalkyl)phenyl]formamides 1 are dehydrated with POCl3 to give the corresponding 2-(1-azidoalkyl)phenyl isocyanides 2, which are then treated with NaH in DMF at 0° to give quinazolines 6 in satisfactory yields via cyclization of 1-(2-isocyanophenyl)alkylideneamine intermediates 4. This methodology can be applied to the synthesis of the 7-azaanalogs of quinazolines, i.e., pyrido[3,4-d]pyrimidines 9. Copyright
