7556-99-2

Usage

Uses

Used in Medicinal Chemistry:
7-Chloroquinazoline is utilized as a pharmaceutical intermediate for the synthesis of various compounds with therapeutic potential. Its unique structure and reactivity contribute to the development of new drugs with antitumor, antibacterial, and antifungal properties.
Used in Pharmaceutical Industry:
7-Chloroquinazoline serves as a key building block in the creation of novel pharmaceuticals, enhancing the discovery and synthesis of compounds with significant medicinal value.
Used in Agrochemical Industry:
In addition to its applications in medicine, 7-chloroquinazoline is also employed as an intermediate in the synthesis of agrochemicals, contributing to the development of new compounds for agricultural applications and potentially improving crop protection and yield.

InChI:InChI=1/C8H5ClN2/c9-7-2-1-6-4-10-5-11-8(6)3-7/h1-5H

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 77287-34-4 formamide 
• 1644428-66-9 N-[2-(azidomethyl)-5-chlorophenyl]formamide 
• 1644428-74-9 1-(azidomethyl)-4-chloro-2-isocyanobenzene 
• 1189783-18-3 N-[5-chloro-2-(chloromethyl)phenyl]formamide 

Relevant academic research and scientific papers

A novel synthesis of quinazolines by cyclization of 1-(2-isocyanophenyl) alkylideneamines generated by the treatment of 2-(1-azidoalkyl)phenyl isocyanides with NaH

A new and efficient method for the synthesis of quinazolines has been developed. Thus, N-[2-(1-azidoalkyl)phenyl]formamides 1 are dehydrated with POCl3 to give the corresponding 2-(1-azidoalkyl)phenyl isocyanides 2, which are then treated with NaH in DMF at 0° to give quinazolines 6 in satisfactory yields via cyclization of 1-(2-isocyanophenyl)alkylideneamine intermediates 4. This methodology can be applied to the synthesis of the 7-azaanalogs of quinazolines, i.e., pyrido[3,4-d]pyrimidines 9. Copyright

Palladium complex-catalyzed intermolecular reductive N-heterocyclization: novel synthesis of quinazoline derivatives from 2-nitrobenzaldehyde or 2-nitrophenyl ketones with formamide

A combination of the palladium complex PdCl2(PPh3)2 with MoCl5 shows a high catalytic activity for the intermolecular reductive N-heterocyclization of 2-nitrobenzaldehyde or 2-nitrophenyl ketones with formamide to give the corresponding quinazoline derivatives in moderate yields.For example, in the reaction of 2-nitrobenzaldehyde with formamide, quinazoline was obtained in 46percent yield.We assume that the present reaction proceeds via an active nitrene intermediate which could be generated by selective deoxygenation of nitro group by carbon monoxide.Keywords: Palladium; Molybdenum; Carbon monoxide; Nitrene; Reductive N-heterocyclization