75560-39-3Relevant academic research and scientific papers
Synthesis of [1-11C]ethyl iodide from [11C]carbon monoxide and its application in alkylation reactions
Eriksson, Jonas,Antoni, Gunnar,Langstroem, Bengt
, p. 723 - 731 (2007/10/03)
A method is presented for preparing [1-11C]ethyl iodide from [11C]carbon monoxide. The method utilizes methyl iodide and [ 11C]carbon monoxide in a palladium-mediated carbonylation reaction to form a mixture of [1-11C]acetic acid and [1-11C]methyl acetate. The acetates are reduced to [1-11C]ethanol and subsequently converted to [1-11C]ethyl iodide. The synthesis time was 20 min and the decay-corrected radio-chemical yield of [1-11C]ethyl iodide was 55 ± 5%. The position of the label was confirmed by 13C- labelling and 13C-NMR analysis. [1-11C]Ethyl iodide was used in two model reactions, an O-alkylation and an N-alkylation. Starting with approximately 2.5 GBq of [11C]carbon monoxide, the isolated decay-corrected radiochemical yields for the ester and the amine derivatives were 45 ± 0.5% and 25 ± 2%, respectively, based on [ 11C]carbon monoxide. Starting with 10 GBq of [11C]carbon monoxide, 0.55 GBq of the labelled ester was isolated within 40 min with a specific radioactivity of 36 GBq/μmol. Copyright
A Dynamic Equilibrium of Oxaphosphetanes
Geletneky, Christian,Foersterling, Frank-Holger,Bock, Willi,Berger, Stefan
, p. 2397 - 2402 (2007/10/02)
The course of the Wittig reaction was investigated by rapid injection NMR spectroscopy.Rate constants for the formation of oxaphosphetanes were determined.A new dynamic equilibrium of oxaphosphetanes was observed for the first time.The solvent and substituent dependence of the new effect was investigated.By labeling various oxaphosphetanes with 13C and 17O the lithium salt dependence of the new equilibrium was shown.A lithium adduct of oxaphosphetanes under these conditions is proposed. - Key Words: Wittig reaction / Rapid injection NMR / Dynamic NMR / Oxaphosphetanes
