75560-74-6Relevant academic research and scientific papers
Selective 1,2-Aminoisothiocyanation of 1,3-Dienes Under Visible-Light Photoredox Catalysis
Guo, Weisi,Wang, Qian,Zhu, Jieping
supporting information, p. 4085 - 4089 (2020/12/25)
Selective three-component 1,2-diamination of 1,3-dienes with concurrent introduction of two orthogonally protected amino groups remains unknown despite its significant synthetic potential. We report herein that reaction of conjugated dienes with N-aminopy
Tandem Cyclopropanation/Vinylogous Cloke-Wilson Rearrangement for the Synthesis of Heterocyclic Scaffolds
Piotrowski, Mathew L.,Kerr, Michael A.
supporting information, p. 7624 - 7627 (2019/01/03)
Cyclopropanation of 1,3-dienes with ethyl 2-formyldiazoacetate under rhodium catalysis results in either a tandem cyclopropanation/Cloke-Wilson rearrangement or a vinylogous variant, depending on the diene used. These adducts may be subjected to an oxygen
Electrochemical selenium- and iodonium-initiated cyclisation of hydroxy-functionalised 1,4-dienes
R?se, Philipp,Emge, Steffen,Yoshida, Jun-Ichi,Hilt, Gerhard
supporting information, p. 174 - 183 (2015/02/19)
The cobalt(I)-catalysed 1,4-hydrovinylation reaction of allyloxytrimethylsilane and allyl alcohol with substituted 1,3-dienes leads to hydroxy-functionalised 1,4-dienes in excellent regio- and diastereoselective fashion. Those 1,4-dienols can be converted
Synthesis and anti-inflammatory activity of phenylbutenoid dimer analogs
Kim, Sung-Soo,Fang, Yuanying,Park, Haeil
, p. 1676 - 1680 (2015/07/15)
Several phenylbutenoid dimer (PBD) analogs were synthesized and evaluated for their inhibitory activities against nitric oxide (NO) production and TNF-α release. The PBD analogs were synthesized via Diels - Alder and subsequent Schlosser reactions as key steps. Among the tested compounds, two analogs (8c, 8f) exhibited much stronger inhibitory activity against LPS-stimulated NO production and TNF-α release in RAW 264.7 cells than that of wogonin.
Aqueous Wittig reactions of semi-stabilized ylides. A straightforward synthesis of 1,3-dienes and 1,3,5-trienes
McNulty, James,Das, Priyabrata
experimental part, p. 5737 - 5740 (2009/12/06)
A direct synthesis of 1,3-dienes and 1,3,5-trienes from the reaction of semi-stabilized ylides and a range of saturated and unsaturated aldehydes is reported in water as solvent, employing sodium hydroxide as base. The water-soluble phosphine oxide side p
Modular synthesis of tetrahydrofluorenones from 5-alkylidene Meldrum's acids
Fillion, Eric,Dumas, Aaron M.,Hogg, Sylvia A.
, p. 9899 - 9902 (2007/10/03)
The one-pot synthesis of tetrahydrofluorenones, the core 6-5-6 tricyclic structural motif found in norditerpenoid natural products, from alkylidene Meldrum's acids via thermal Diels-Alder/BF3·OEt 2-catalyzed Friedel-Crafts acylation
Microwave-assisted minutes synthesis of bioactive phenylbutanoids occurring in Zingiber cassumunar
Joshi,Singh,Sharma,Sinha
, p. 370 - 373 (2007/10/03)
Microwave-assisted condensation of benzaldehyde (3a,b) with acetone in aqueous sodium hydroxide adsorbed on basic alumina provides phenylbutenone (4a-4b) in 68-71% yield within 4 min, which upon further reduction with sodium borohydride and basic alumina gives phenylbutenol (5a,b) in 91-94% yield within 2 min. Dehydration of 5 with anhydrous copper (II) sulfate gives phenylbutadiene (1a,b), a metabolite of Zingiber cassumunar, within 3 min in 42-48% yield, respectively. All the steps involve environmental friendly solvents and reagents, mild reaction conditions, and overall formation of product 1a,b from 3a,b in 34-38% yield within 9 min under microwave irradiation. 2005 Springer Science+Business Media, Inc.
PHENYLBUTENOID DIMERS FROM THE RHIZOMES OF ZINGIBER CASSUMUNAR
Jitoe, Akiko,Masuda, Toshiya,Nakatani, Nobuji
, p. 357 - 364 (2007/10/02)
Two new phenylbutenoid dimers, (+/-)-trans-3-(2,4,5-trimethoxyphenyl)-4-cyclohexene and cis-1,2-biscyclobutane, have been isolated from the fresh rhizomes of Zingiber cassumunar along with the two known phenylbutenoid dimers.Their structures were elucidated by spectroscopic and chemical methods.The stereochemistry of these cyclohexene compounds was clarified on the basis of 1H NMR data of their derivatives.The substituted positions for the 3,4-dimethoxystyryl groups of the cyclobutane compound were confirmed from a Cope rearrangement product in the pyrolysis of the cyclobutane, and the stereochemistry of the cyclobutane was confirmed by 1H NMR evidence.Key Word Index - Zingiber cassumunar; Zingiberaceae; rhizomes; phenylbutenoid; dimer.
