75564-41-9Relevant academic research and scientific papers
Regioselective preparation of N-substituted 3,5-diamino-1,2,4-oxadiazoles
Suyama, Takayuki,Suzuki, Noriyuki,Nishimura, Masami,Saitoh, Yuka,Ohkoshi, Hiroyuki,Yamaguchi, Jun-Ichi
, p. 873 - 876 (2007/10/03)
Regioselective preparation of 3,5-diamino-1,2,4-oxadiazoles which have a substituent on one or the other amino group has been developed. When 1-substituted 3-cyano-2-ethylisourea (2) was allowed to react with hydroxylamine under basic conditions, 5-amino-3-(substituted amino)-1,2,4-oxadiazole (3) was obtained in good yield. On the other hand, 3-amino-5-(substituted amino)-1,2,4-oxadiazoles (4), a regioisomer of 3, could be synthesized by the reaction of N,O-bis(trimethylsilyl)hydroxylamine (9) with 2 or 1-substituted 3-cyano-2-methylisothiourea (1) and subsequent alcoholysis.
