75565-44-5Relevant academic research and scientific papers
Synthesis and H2-Antagonistic Activity of N3,N5-Substituted 1,2,4-Oxadiazole-3,5-diamines. 26th Communication: H2-Antihistaminics
Kraemer, I.,Schunack, W.
, p. 1011 - 1014 (2007/10/02)
N5-propyl>-1,2,4-oxadiazole-3,5-diamines and N5-ethyl>-1,2,4-oxadiazole-3,5-diamines with different N3-substituents were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium.They were synthesized by nucleophilic substitution of the appropriate 5-trichloromethyloxadiazoles with the amines 3 and 11.Of the prepared substances 10a,c in particular showed high H2-antagonistic activity. - Key words: Histamine H2-antagonists; Histamine H2-receptors; 1,2,4-Oxadiazole-3,5-diamines, N3,N5-substituted
